Key Statistics for Cancers of Unknown Primary
How common are cancers of unknown primary?
The exact number of cancers of unknown primary (CUP) diagnosed each year is unknown, because some cancers start out being diagnosed as unknown primary, but the primary site is found later. Still, the American Cancer Society estimates that about 37,370 cases of cancer of unknown primary will be diagnosed in 2025 in the United States. This number represents about 2% of all cancers. As more sophisticated lab tests become available to determine where a cancer started, the number of cancers of unknown primary may go down.
Visit the for more key statistics.
- Written by
- References
The American Cancer Society medical and editorial content team
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing.
American Cancer Society. Facts & Figures 2025. American Cancer Society. Atlanta. 2025.
Bochtler T, L?ffler H, Kr?mer A. Diagnosis and management of metastatic neoplasms with unknown primary. Semin Diagn Pathol. 2018 May;35(3):199-206. doi: 10.1053/j.semdp.2017.11.013. Epub 2017 Nov 26. PMID: 29203116.
Howlader N, Noone AM, Krapcho M, et al (eds). SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER website, April 2017.
Mnatsakanyan E, Tung WC, Caine B, Smith-Gagen J. Cancer of unknown primary: Time trends in incidence, United States. Cancer Causes Control. 2014 Jun;25(6):747-57. doi: 10.1007/s10552-014-0378-2. Epub 2014 Apr 8.
Varadhachary GR, Lenzi R, Raber MN, Abbruzzese JL. Carcinoma of Unknown Primary In: Neiderhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. ´¡²ú±ð±ô´Ç´Ú´Ú¡¯²õ Clinical Oncology. 5th ed. Philadelphia, PA. Elsevier: 2014:1792-1803.
Last Revised: January 16, 2025
American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.
American Cancer Society Emails
Sign up to stay up-to-date with news, valuable information, and ways to get involved with the American Cancer Society.